The Constellation in the Inner Harbor in Baltimore, September 2009

The second Constellation, a sloop designed by John Lenthall and constructed at the Norfolk Navy Yard, was commissioned on 28 July 1855 and departed under Captain Charles H. Bell for a 3-year cruise with the Mediterranean Squadron to protect American interests. While on station, Constellation was dispatched to protect American lives and property at Malaga, Spain, in July 1856 during a revolution in that country. While cruising in the Sea of Marmora the same year, she rescued a barque in distress, and received an official message in appreciation from the court of the Austrian emperor.

Constellation was detached from the Mediterranean Squadron on 17 April 1858 and after a brief cruise in Cuban waters where she safeguarded American commerce against unlawful search on the high seas, returned to the New York Navy Yard on 5 June. She was then decommissioned at Boston on 13 August. Re-entering active service in June 1859 as flagship of the African Squadron, Constellation took station off the mouth of the Congo River on 21 November 1859, she captured the brig Delicia during the mid watch on 21 December 1859 "without colors or papers to show her nationality… completely fitted in all respects for the immediate embarcation [sic] of slaves..." On 26 September 1860, after her entire crew had turned-to to "trim the vessel for the chase" (even wetting the sails "so they would push the sloop along"), Constellation captured the "fast little bark" Cora (which showed no flag and carried 705 slaves), nearly running down the slaver in the darkness. When captured, the slavers were impounded and sold at auction, their captains required to post bond and await trial, while their crews were landed at the nearest port and released. The newly freed slaves were taken to Monrovia, Liberia. The U.S. government paid a bounty of $25 for each freed slave freed, and "prize money" for each impounded ship to be divided among the crew proportionally according to rank.

On 19 April 1861, one week after Confederate forces fired on Fort Sumter, President Abraham Lincoln issued a proclamation declaring a blockade of southern ports and on 2 May called for the enlistment of 18,000 additional seamen. Constellation's seizure of the brig Triton on 21 May 1861 proved one of the U.S. Navy's first captures of the Civil War. Although Constellation's men found no slaves on board the captured vessel, they noted that "...every preparation for their reception had been made..."

Ordered home in August 1861, Constellation, Captain Thomas A. Dornin in command, reached Portsmouth (New Hampshire) Navy Yard on 28 September, but soon received orders to the Mediterranean, where her economy and endurance would enable her to outperform less reliable steam ships, to guard Union merchant ships against attack by Confederate cruisers and commerce raiders. On 11 March 1862 Constellation sailed from Portsmouth under the command of Commodore Henry K. Thatcher. Arriving on 19 April, Constellation spent two years (April 1862 to May 1864) engaged in patrolling, at one point assisting in blockading the Confederate warship Sumter, abandoned by her captain and officers except for a token, caretaker crew, at Gibraltar, and later participating in the attempt to prevent the Confederate Navy from taking possession of the British-built steamer Southerner in Italy for use as a commerce raider.

Returning home via the West Indies, Constellation operated briefly in the latter region, wrote one of her sailors, "trying to capture Rebel privateers and cruisers and blockade runners. The process of reasoning ... seems to be that our ship is supposed to be in European waters, and there is no United States warship resembling her cruising about here, and consequently she might approach closely to a Rebel vessel or blockade runner without exciting suspicion..."

With the terms of enlistment of most of the crew expiring, Admiral David G. Farragut ordered Constellation to Hampton Roads on 27 November 1864. After pursuing a blockade-runner along th